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Andy Farrell, Moses Rauluni and Kameli Ratuvou are all in the starting team for the clash which sees the two unbeaten teams in Pool D go head to head. Both sides go into the game knowing victory will give them a great chance of making the semi-finals of the competition.
Centre Farrell returns to the team after shaking off the calf injury that prevented him from featuring in the knockout stages of the World Cup, while Fiji captain Rauluni and countryman Ratuvou both feature after an impressive campaign in France that saw them reach the quarter-finals.
England U20 back row Andy Saull could make his Saracens debut after being named on the bench for the game along with Kris Chesney, Neil de Kock, Glen Jackson and Adam Powell.
"It's good to welcome back some of those guys for what we know will be a tough game against Bristol," explained Director of Rugby Alan Gaffney. "Both sides go into the game knowing a victory will put them in a great position so it's sure to be a fiercely contested match.
"We've changed things around again this week to rotate the squad which is something we have to do if we are to compete in all three competitions. It's also important that those who are short of game time get some action and with a series of big games in the next few weeks, we've got some guys on the bench who will get a run out at some point.
"Players like Faz need to get their eye in. He's been with England since June and has been playing a different brand of rugby to that which Saracens play, so he will need a bit of time to adjust. Moses came off the bench last week and demonstrated some of the form which made him a stand out player at the World Cup while Kameli is another who needs some time.
"We're putting out a side that is capable of winning the game and it should be an entertaining game - and with the prospect of being just three games away from a Twickenham final, I know it's a match that the players are really looking forward to."
Fabio Ongaro misses the match with a hamstring injury while Cobus Visagie, who is back in full training, is likely to feature in the Guinness A-League match at Harlequins on Monday. Brent Russell, Francisco Leonelli and Matias Aguero are all back in light training.
Saracens team vs Bristol
15 Richard Haughton
14 Rodd Penney
13 Kevin Sorrell ©
12 Andy Farrell
11 Kameli Ratuvou
10 Gordon Ross
9 Moses Rauluni
1 Nick Lloyd
2 Matt Cairns
3 Cencus Johnston
4 Tom Ryder
5 Hugh Vyvyan
6 Paul Gustard
7 David Seymour
8 Ben Skirving
16 Andy Kyriacou
17 Tom Mercey
18 Kris Chesney
19 Andy Saull
20 Neil de Kock
21 Glen Jackson
22 Adam Powell | 
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